A mild formulation that gently moisturises and removes unwanted impurities, without stripping the skin’s natural protective oils and emollients, or upsetting the pH balance. Soothing and fragrance free, daily use relieves the dryness often caused by medicated skin products without itching or irritation

After topical application of Metvix (methyl aminolevulinate), porphyrins accumulate intracellularly in the treated skin lesions. The intracellular porphyrins (including PplX) are photoactive, fluorescing compounds and, on light activation in the presence of oxygen, singlet oxygen is formed, which causes damage to cellular compartments, in particular the mitochondria. Light activation of accumulated porphyrins leads to a photochemical reaction and thereby phototoxicity to the light-exposed target cells

Epiduo contains a combination of adapalene and benzoyl peroxide. Adapalene is a retinoid-like compound that is a potent modulator of cellular differentiation and keratinisation and has anti-inflammatory properties. This profile suggests that the cell-mediated inflammatory component of acne is reduced by adapalene. Benzoyl peroxide has been shown to have antimicrobial activity, particularly against Propionibacterium acnes, which is abnormally present in the acne-affected pilosebaceous unit. In addition, benzoyl peroxide has demonstrated exfoliative and keratolytic activities and is sebostatic, counteracting the excessive sebum production associated with acne

Combination of 0.3% adapalene (a retinoid) and 2.5% benzoyl peroxide (an antibiotic and skin-peeling agent) that can decrease the number and severity of acne pimples and promote quick healing of pimples that do appear

Efracea contains doxycycline, an antibacterial that has been shown to inhibit neutrophil activity and several pro-inflammatory reactions, including those associated with phospholipase A2, endogenous nitric oxide and interleukin-6. It works by altering the pathophysiology of the inflammatory lesions of rosacea that is, in part, a manifestation of a neutrophil-mediated process. The OD 40mg modified release is designed to stay below the antimicrobial threshold to reduce commonly occurring side effects, while retaining an anti-inflammatory action

Adapalene is a retinoid-like compound that has been demonstrated to have anti-inflammatory properties

Aklief cream contains 50 micrograms (mcg/g) (w/w) trifarotene, which is a chemically stable, terphenyl acid derivative with retinoid-like activity. It is a potent RARγ agonist (retinoid acid receptor γ agonist), characterized by its high specificity to this receptor over RARα & RARβ (50- and 8-fold, respectively, with no Retinoid X Receptor (RXR) activity). In addition, trifarotene modulates retinoid target genes (differentiation and inflammatory processes) in immortalized keratinocytes and reconstructed epidermis.

Acnecide is a 5% preparation of benzoyl peroxide, which is an established and effective keratolytic agent with antibacterial properties. It has been shown to be effective in reducing the local population of Propionibacterium acnes, leading to a reduction in the production of irritant fatty acids in the sebaceous glands

Tetralysal contains 408mg of lymecycline, equivalent to 300mg tetracycline base. Tetracyclines provide bacteriostatic action at the available plasma and tissue concentrations and are effective against intracellular and extracellular organisms. Their mechanism of action is based on the inhibition of ribosomal protein synthesis. Tetracyclines block the access of the bacterial aminoacyl-tRNA to the mRNA-ribosome complex by binding to the 30S subunit of the ribosome, thus preventing the addition of amino acids to the growing peptide chain in protein synthesis. When given at therapeutically attainable concentrations, their toxic effect is limited to the bacterial cells. The exact mechanisms by which tetracyclines reduce lesions of acne vulgaris have not been fully elucidated, however, the effect appears to result in part from antibacterial activity. Following oral administration, the drugs inhibit the growth of susceptible organisms (mainly Propionibacterium acnes) on the surface of the skin and reduce the concentration of free fatty acids in sebum. The reduction in free fatty acids in sebum may be an indirect result of the inhibition of lipase-producing organisms which convert triglycerides into free fatty acids or maybe a direct result of interference with lipase production in these organisms. Free fatty acids are comedogenic, and are believed to be a possible cause of the inflammatory lesions, e.g. papules, pustules, nodules, cysts, or acne. However, other mechanisms also appear to be involved because clinical improvement of acne vulgaris with oral tetracycline therapy does not necessarily correspond with a reduction in the bacterial flora of the skin or a decrease in the free fatty acid content of sebum

Uvistat Sun Creams are 100% fragrance-free and specially formulated for sensitive skin. Uvistat provides high UVA/UVB protection. Uvistat SPF50 Lipscreen contains Vitamin E and Oil to help protect against cold sores and dry chapped lips.