Garments and tubular sleeves made from medical-grade, sericin-free fibroin silk, treated with a non-migrating antimicrobial agent.

Ixekizumab is an IgG4 monoclonal antibody that binds with high affinity (<3 pM) and specificity to interleukin 17A (both IL-17A and IL-17A/F). Elevated concentrations of IL-17A have been implicated in the pathogenesis of psoriasis by promoting keratinocyte proliferation and activation, as well as in the pathogenesis of psoriatic arthritis by driving inflammation leading to erosive bone damage and pathological new bone formation. Neutralisation of IL-17A by ixekizumab inhibits these actions.

Baricitinib is a selective and reversible inhibitor of Janus kinase (JAK)1 and JAK2. In isolated enzyme assays, baricitinib inhibited the activities of JAK1, JAK2, Tyrosine Kinase 2 and JAK3 with IC50 values of 5.9, 5.7, 53 and > 400 nM, respectively. Janus kinases (JAKs) are enzymes that transduce intracellular signals from cell surface receptors for a number of cytokines and growth factors involved in haematopoiesis, inflammation and immune function. Within the intracellular signalling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which activate gene expression within the cell. Baricitinib modulates these signalling pathways by partially inhibiting JAK1 and JAK2 enzymatic activity, thereby reducing the phosphorylation and activation of STATs.

Immunosupressant

Robinul contains glycopyrrolate, which is a quaternary ammonium compound and, as such, is absorbed through the skin in negligible amounts only

Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal subunit of susceptible microorganisms and suppressing protein synthesis. Erythromycin is usually active against most strains of Gram-positive, Gram-negative, mycoplasm and other organisms in clinical infections

Leave-on emollient that quickly softens, protects and moisturises dry, cracked and sore skin

Emollient cream

An emollient lotion containing light liquid paraffin 4%, cetomacrogol, white soft paraffin 10%, hypoallergenic anhydrous

E45 Cream contains hypoallergenic lanolin, light liquid paraffin and white soft paraffin, all of which have emollient moisturising properties